FABIAN-variant was first released at the end of 2021 and is updated regularly. This page summarizes recent changes. If you are missing a feature or discover a bug, please submit a ticket via email.
The infrastructure of FABIAN-variant is designed to be easily extended when new versions of the underlying data are released. The current number of supported models and transcription factors is listed in the lower left corner of the homepage.
2026-07-07
- Full release of FABIAN-variant 2026 – major update
- New URL: https://fabianapp.org/variant26/
- 40,315 PWM and TFFM models for human, plus 1,259 BPNet deep learning models from JASPAR 2026
- Support for the mouse genome (GRCm38, GRCm39) with 35,990 models
- Prediction models for 1,420 human and 1,355 mouse heterodimer TF complexes (e.g., AHR::ARNT)
- Known TFBS data expanded to five sources: ENCODE, ReMap 2022, ChIP-Atlas, UniBind, and Ensembl Regulation
- RESTful JSON API for programmatic access
- Standalone version for local execution
- Backend rewritten in Rust, reducing runtime by ~70%
- Several usability improvements
2025-12-20
- Pre-release of FABIAN-variant 2026
2026-04-19
- Fix a bug in batch mode where submitting exactly 100 variants incorrectly returned an error
2025-05-27
- Update the default genome and examples to GRCh38/hg38 (GRCh37/hg19 is still available in the dropdown menu)
2025-04-30
- Improve server-side job scheduling: Faster job start times and more efficient resource utilization (runtime reduced by approx. 50% for single-variant searches and approx. 25% for VCF searches)
2023-07-06
- Implement three advanced options for the analysis of VCF files:
- When the panel with VCF options is hidden, a summary of the selected VCF options is now displayed:
- Fix 'Rename failed' error that occurred in rare cases when analysing VCF files
2023-04-13
- Fix a bug where the polymorphism filter was not applied to the analysis of some VCFs.
The status of the polymorphism filter is displayed in the computation log on the results page:
2022-11-08
- Analyse VCF lines without GT and DP values (see documentation for details)
- Add examples for programmatic access to FABIAN-variant to the documentation
2022-10-22
- Improve server-side job scheduling (single, batch and VCF jobs now run in separate queues), show hint on the results page in case an analysis has to wait in the queue
2022-05-26
- Change the yellow colour of guanine in the PWM sequence logos so that it is better visible against the white background
- Add links to our publication to the bottom of the homepage and the results page (if you like FABIAN-variant, please cite us)
2022-04-22
- Change calculation of the per-model score based on Ref and Alt scores (see documentation for details)
- Change calculation of the combined score when both PWMs and TFFMs exist for the same transcription factor (see documentation for details)
- Reorganize the sort and filter options on the results page, add option 'Prefer TFFMs' and add more documentation for the options
- Add more explanation about known TFBSs
2022-04-15
- The homepage options to select transcription factors individually and to paste transcription factors by name are now linked, so that changing one affects the other (this makes it easier to create and reuse a list of transcription factors)
- Break long lines in the log
2022-04-09
- Add this changelog
- Update the tutorial with a new WGS VCF file with 4 million variants (instead of 8 million)
- When deleting results, the results page in the browser is now cleared as well
2022-03-30
- Improve homepage layout for small screens and tablets
- Move genome selection on the homepage next to the variant input field
- Add better information about accepted input formats to the homepage
2022-03-15
- Implement full support for GRCh38/hg38 to VCF analysis
- Add deletion function for results
- Add automatic pagination for VCF searches with more than 100 variants
2022-01-31
- Add sequence logos to the detailed results page (PWM logos are custom-generated, TFFM logos from JASPAR)
2021-12-20
- Initial version of FABIAN-variant released